IVM is a new technique that was introduced to assisted reproductive techniques (ART) in the late 90’s. For a group of special selected patients (patients with a high risk for or a history of severe ovarian hyperstimulation syndrome, OHSS) IVM might be safer than regular IVF-stimulation since it involves only a short time of hormonal stimulation and the oocytes are collected while they are immature.


Once the immature oocytes are collected they are cultured in special media supplemented with hormones for 24-48 hours.

The next step is to check the maturity and to inject the mature ones with the husband’s sperm (ICSI). The following steps are similar to IVF/ICSI steps that involve culturing the oocyte, fertilization check, embryo culture and grading and finally embryo transfer.

Although IVM provides less risk of ovarian stimulation complication, it has to be taken into consideration that since the ovary simulation is shorter and milder, a lower number of mature oocytes is obtained with this technique compared to regular IVF stimulation. Also, the chances of pregnancy achieved with this technique are below that compared to normal hormonal stimulation cycle.

IVM could be considered for:

  • Females with a high risk of Ovarian Hyperstimulation Syndrome (OHSS), including Polycystic Ovarian Syndrome (PCOS).
  • Females with oocyte maturity problems: if the couple had previous IVF trials where low oocyte maturity percentage was obtained
  • As a fertility preservation technique, when there is only a short time frame before cancer treatment (chemotherapy or radiation) has to be started

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